Medicine Overview of Bosulif 100mg
Uses of Bosulif 100mg
BOSULIF (bosutinib) is a prescription medicine used for the treatment of adult patients with:
- Newly-diagnosed chronic phase Ph+ chronic myelogenous leukemia (CML). This indication is approved under accelerated approval based on molecular and cytogenetic response rates. Continued approval for this indication may be contingent upon verification and confirmation of clinical benefit in an ongoing long-term follow up trial.
- Chronic, accelerated, or blast phase Ph+ CML with resistance or intolerance to prior therapy.
Bosulif 100mg side effects
- The common side effects of Bosulif 100mg for those patients who are newly diagnosed include: diarrhea, nausea, low platelet counts, rash, stomach pain, and changes in liver function tests.
- The common side effects of Bosulif 100mg for those patients who no longer benefit from or did not tolerate other treatment include: diarrhea, nausea, stomach pain, rash, low platelet counts, vomiting, low red blood cell counts, tiredness, fever, cough, headache, changes in liver function tests, and swelling.
How to use Bosulif 100mg
- Take Bosulif 100mg exactly as prescribed by your doctor.
- Do not change your dose or stop taking Bosulif 100mg without first talking with your doctor.
- Take Bosulif 100mg with food.
- Swallow Bosulif 100mg tablets whole. Do not crush, break, or cut BOSULIF tablets. Do not touch or handle crushed or broken Bosulif 100mg tablets.
How Bosulif 100mg works
Bosutinib is a type of drug called a protein tyrosine kinase inhibitor (TKI). Tyrosine kinases are proteins that act as chemical messengers to stimulate cancer cells to grow. Bosutinib blocks (inhibits) a protein made by CML cells that have the Philadelphia chromosome. Blocking this protein stops the leukaemia cells growing.
In Depth Information on Bosulif 100mg
Expert advice for Bosulif 100mg
- Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
- You should not eat grapefruit or drink grapefruit juice when you are taking this drug because it can react with the drug.
- If you take an antacid or H2 blocker medicine, take it at least 2 hours before or 2 hours after BOSULIF. If you take a Proton Pump Inhibitor (PPI) medicine, talk to your doctor or pharmacist.
- If you miss a dose of Bosulif 100mg, take it as soon as you remember. If you miss a dose by more than 12 hours, skip that dose and take your next dose at your regular time. Do not take 2 doses at the same time.
- If you take too much Bosulif 100mg, call your doctor or go to the nearest hospital emergency room right away.
- Tell your doctor right away if you get respiratory tract infections, loss of appetite, headache, dizziness, back pain, joint pain, or itching while taking Bosulif 100mg. These may be symptoms of a severe allergic reaction.
- Your doctor may change your dose, temporarily stop, or permanently stop treatment with BOSULIF if you have certain side effects.
- BOSULIF may cause fertility problems in females and males. This may affect your ability to have a child. Talk to your doctor if this is a concern for you.
Bosulif 100mg related warnings
Special precautions for Bosulif 100mg
Bosulif 100mg may cause kidney problems. Your doctor should do tests to check your kidney function when you start treatment with Bosulif 100mg and during your treatment. Call your doctor right away if you get any of the following symptoms during your treatment with Bosulif 100mg:
- you urinate more often than normal
- you urinate less often than normal
- you make a much larger amount of urine than normal
- you make a much smaller amount of urine than normal