Lenvat (lenvatinib) is a kinase inhibitor that is indicated for
- Differentiated Thyroid Cancer (DTC): single agent for patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory DTC.
- Renal Cell Cancer (RCC): in combination with everolimus, for patients with advanced RCC following one prior anti-angiogenic therapy.
- Hepatocellular Carcinoma (HCC): as first line therapy in patients with unresectable hepatocellular carcinoma
DOSAGE AND ADMINISTRATION
- Recommended dose (DTC): 24 mg orally, once daily.
- Recommended dose (RCC): 18 mg lenvatinib 5 mg everolimus, orally, once daily.
- Recommended dose (HCC): 12 mg orally, once daily (for adults weighing >_60 Kg). 8 mg orally, once daily for adults weighing <60 kg).
- Administration Instructions.
- Dose Modifications for DTC and RCC.
- In patients with severe renal or hepatic impairment, the dose is 14 mg once daily in DTC and 10 mg once daily in RCC.
lenvatinib Side Effects
- 1.tiredness 2.joint and muscle pain 3.weight loss
- 4.mouth sores 5.vomiting 6.stomach (abdomen) pain
- 7. decreased appetite 8.nausea 9.headache
- 10.rash, redness, itching, or peeling of your skin on your hands and feet
- 11. Hoarseness
The most common side effects of lenvatinib in people treated for kidney cancer include:
- 1.tiredness 2.decreased appetite 3.nausea
- 4. swelling in your arms and legs 5.stomach (abdomen) pain 6.rash
- 7.joint and muscle pain 8.vomiting 9.mouth sores
- 10.cough 11.trouble breathing 12.weight loss 13.bleeding
Lenvat’s brand name is LENVIMA by Eisai Inc. Lenvat is a generic oncologic prescription medicine from Natco (similar drugs like Lenvanix), which is one of the biggest pharmaceutical company in India.